Endocrine Abstracts

We would like to present a case which, through unexpected results, caused us to examine the communication, both written and verbal, that is provided to patients prior to undergoing dynamic tests in our unit, and which subsequently led to a change in our practice.A 48-year-old lady was referred from the GP with a raised testosterone of 5.0 nmol/l (reference range 0.2–2.9 nmol/l), irregular periods and late onset hirsutism. A low dose dexamethasone te...

The development of insulin resistance and type 2 diabetes mellitus (T2DM) in obesity involves (a) adipose inflammation, and (b) restricted adipose expansion with ectopic lipid deposition. Metalloproteinases (MPs) and tissue inhibitors of metalloproteinases (TIMPs) constitute a key regulatory system in inflammation and tissue remodelling. Evidence of MP and TIMP involvement in adipose tissue inflammation and modulation of adipose expansion is currently restricted to work in adi...

Background: Microalbuminuria is an early marker of diabetic nephropathy in type 2 diabetes mellitus (T2DM) which predicts the development of later stages of nephropathy. Thiazolidinediones are a class of oral hypoglycaemic drugs used in diabetes glycaemic management that act through PPARγ receptors. Studies have suggested they significantly reduce urinary albumin excretion; however, most trials were small. We therefore performed a systematic review to clarify the effectiv...